How to Take Avmapki™ Fakzynja™ Co‑Pack | Dosing Instructions
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Taking Avmapki Fakzynja Co‑Pack

Discover what you need to know about being on treatment. Explore everything from tools for tracking dosing to informational videos on side effect management.

How to take Avmapki Fakzynja Co‑Pack

Each cycle consists of 3 weeks of treatment with 1 week off.
Avmapki should be taken twice a week (in the morning on Day 1 and Day 4), while Fakzynja should be taken twice a day every day. It’s important to follow the dosing schedule prescribed by your healthcare provider.

AVMAPKI™ capsule

Avmapki: 4 capsules (3.2 mg) = 1 dose

  • On Weeks 1, 2, and 3, take 3.2 mg (4 capsules) on Day 1 and Day 4
  • On Week 4, take a one-week break
  • Take each dose at the same time with food
  • Swallow the capsules whole. Do not chew, break, or open the capsules
  • Keep refrigerated in original bottle
FAKZYNJA™ tablet

Fakzynja: 1 tablet (200 mg) = 1 dose

  • On Weeks 1, 2, and 3, take 200 mg (1 tablet) 2 times a day
  • On Week 4, take a one-week break
  • Take with food
  • Swallow the tablets whole. Do not chew, break, or crush the tablets
  • Keep refrigerated in original bottle

Take Avmapki Fakzynja Co‑Pack exactly as your healthcare provider tells you to, and do not change your dose or stop taking it without talking to your healthcare provider. If you develop certain side effects, your healthcare provider may change your dose, temporarily stop treatment, or completely stop treatment.

Dosing schedule calendar for AVMAPKI™ FAKZYNJA™ CO-PACK

Product images shown are not actual size.

Watch the dosing video

Learn how Avmapki Fakzynja Co-Pack should be taken by watching this video.

Illustration showing Avmapki® capsules and Fakzynja® tablets with dosing icons

The treatment was a combination of two medications, and I took both of them by mouth. My doctor told me to take the medications with food. So it helps for me to set an alarm on my phone as a reminder to take the medication.

— Mary

Avmapki Fakzynja Co-Pack Digital Companion

The Avmapki Fakzynja Co-Pack Digital Companion, available via the free Medisafe app, is equipped with tools to help you along your treatment journey by providing:

  • Dosing reminders
  • Dosing video content
  • Side effect tracking
  • Verastem CaresTM information

Scan the QR code or click here to download the Medisafe app now

Smartphone displaying the Avmapki® Fakzynja® Co-Pack Digital Companion in the Medisafe app

Scan the QR code or click here to download the Medisafe app now

Stay on track with your treatment

Use these tools to help you track your treatment.

DOSING & SIDE EFFECTS TRACKER

Use this resource to record your medical history, track treatment, log potential side effects, and discuss with your doctor.

Download

Use this version if your healthcare provider reduces the amount of medicine you take.

Download

DOSING CALENDAR

Use this calendar to help track when you take each dose.

Download

Use this version if your healthcare provider reduces the amount of medicine you take.

Download

Monitor and manage side effects

To help monitor and manage possible side effects, it’s important to follow the advice of your healthcare provider and the information below.

Jennifer MacDonald, PharmD, Board Certified Oncology Pharmacist

Jennifer MacDonald, PharmD, Board-Certified Oncology Pharmacist

Jennifer MacDonald is an oncology clinical pharmacy specialist who has cared for patients living with KRAS-mutated recurrent LGSOC. Click on the links below to hear from her about monitoring and managing your eye and skin related side effects during treatment.

Video thumbnail for monitoring eye-related side effects during Avmapki® Fakzynja® Co-Pack treatment

Monitoring eye-RELATED side effects

Learn what to expect and when to contact your healthcare provider about eye related side effects.

Video thumbnail for managing skin-related side effects during Avmapki® Fakzynja® Co-Pack treatment

Managing skin-related side effects

See how skin reactions may be managed 
before and during treatment.

Most side effects of Avmapki Fakzynja Co-Pack were mild to moderate in severity, with 14% of women experiencing side effects that caused them to stop treatment.

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Talk to your healthcare provider

With guidance from their healthcare providers, 84% of patients were able to manage side effects with dose interruptions, and 44% of patients were able to manage side effects with dose reductions, while 14% of patients discontinued treatment.

Eye icon

Be aware of eye problems

Visits to an eye care professional are a routine part of treatment starting before your first dose. Tell your provider right away if you get any new or worsening eye problems. See Important Safety Information to learn more.

For more information on eye safety, watch this video
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Use preventative medicines

Before and during treatment with Avmapki Fakzynja Co-Pack, your healthcare provider will give you a corticosteroid and an antibiotic to help prevent skin reactions. It’s important to know that skin reactions are common with Avmapki Fakzynja Co-Pack and can be severe or life threatening. Be sure to tell your healthcare provider if you develop any new or worsening skin reactions. Please see the Important Safety Information to learn more.

For more information on skin safety, watch this video
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Limit your time in the sun

Take steps to protect your skin during treatment, including taking oral antibiotics and topical sunscreen with at least 30 SPF when you begin treatment, and continue during treatment as directed. Wear protective clothing when you are outdoors. If you have a skin reaction, contact your healthcare provider right away.

A dermatologist prescribed treatment for the acneiform, and [I] was put on the antibiotic. I still had breakouts, but they were manageable and it got better over time.

— Mary

These are not all of the possible side effects of Avmapki Fakzynja Co‑Pack. 
See Important Safety Information to learn more.

Preparing for potential side effects

Learn how your healthcare provider may monitor for and manage possible side effects.

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What to expect from treatment

Download the Treatment Expectations Guide before treatment to help you prepare.

Download Brochure

DOSING & SIDE EFFECTS TRACKER

Keep track of side effects to discuss with your doctor at your next appointment.

Download (Standard Dose) Download (Reduced Dose)

HEAR MARY’S STORY

Listen to Mary describe her treatment experience with Avmapki Fakzynja Co‑Pack.

Watch video
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STAY INFORMED

Receive information and resources to help support you on your treatment journey.

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Before taking Avmapki Fakzynja Co‑Pack, tell your healthcare provider about all of your medical conditions, including if you:

  • have a history of eye or vision problems
  • have had severe skin reactions
  • have liver problems
  • are pregnant or plan to become pregnant. Avmapki Fakzynja Co‑Pack can harm your unborn baby.
    • Females who are able to become pregnant:
      • Your healthcare provider should do a pregnancy test before you start treatment with Avmapki Fakzynja Co‑Pack.
      • You should use effective birth control (contraception) during treatment and for 1 month after the last dose of Avmapki Fakzynja Co‑Pack.
      • Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Avmapki Fakzynja Co‑Pack.
    • Males with a female partner who is able to become pregnant:
      • You should use effective birth control (contraception) during treatment and for 4 months after the last dose of Avmapki Fakzynja Co‑Pack.
  • are breastfeeding or plan to breastfeed. It is not known if Avmapki Fakzynja Co‑Pack passes into your breast milk. Do not breastfeed during treatment and for 2 weeks after the last dose of Avmapki Fakzynja Co‑Pack.

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Avmapki Fakzynja Co‑Pack may affect the way other medicines work, and other medicines may affect how Avmapki Fakzynja Co‑Pack works.

Especially tell your healthcare provider if you take:

  • proton pump inhibitors (PPIs) and H2 receptor antagonists
  • a blood thinner called warfarin

Know the medicines you take. Keep a list of them with you to show your healthcare provider and pharmacist when you get a new medicine.

How should I take Avmapki Fakzynja Co‑Pack?

  • Take Avmapki Fakzynja Co‑Pack exactly as directed by your healthcare provider.
  • Do not change your dose or stop taking Avmapki Fakzynja Co‑Pack without talking to your healthcare provider.
  • If you develop certain side effects your healthcare provider may change your dose, temporarily stop, or completely stop your treatment with Avmapki Fakzynja Co‑Pack.
  • Take Avmapki capsules and Fakzynja tablets with food.
  • If you vomit after taking Avmapki capsules or Fakzynja tablets, do not take an additional dose. Take the next scheduled dose as prescribed by your healthcare provider.

Avmapki capsules:

  • Take each dose at the same time.
  • Swallow the capsules whole. Do not chew, break, or open the capsules.
  • If you miss a dose of Avmapki by more than 24 hours, skip the missed dose and take the next scheduled dose as prescribed by your healthcare provider. Do not take two doses at the same time to make up for a missed dose.

Fakzynja tablets:

  • Swallow the tablets whole. Do not chew, break, or crush the tablets.
  • If you take antacids, take Fakzynja tablets 2 hours before or 2 hours after taking the antacid.
  • If you miss a dose of Fakzynja by more than 6 hours, skip the missed dose and take the next scheduled dose as prescribed by your healthcare provider. Do not take two doses at the same time to make up for a missed dose.

Before and during treatment with Avmapki Fakzynja Co‑Pack, your healthcare provider will give you medicines to apply to your face, scalp, neck, upper chest and upper back, and antibiotic medicines to take by mouth to help prevent skin reactions.

What should I avoid while taking Avmapki Fakzynja Co‑Pack?

  • Limit your time in the sun. Avmapki Fakzynja Co‑Pack can make your skin sensitive to the sun (photosensitivity) and the light from sunlamps and tanning beds. You may burn more easily and get a severe sunburn. Apply daily sunscreen with a Sun Protection Factor (SPF) of 30 or greater and wear a hat and clothes that cover your skin to protect against sunburn. Talk to your healthcare provider if you get a sunburn.

What are the possible side effects of Avmapki Fakzynja Co‑Pack?

Avmapki Fakzynja Co‑Pack may cause serious side effects, including:

  • eye problems. Eye problems are common with Avmapki Fakzynja Co‑Pack and can be severe. Your healthcare provider will send you to see an eye care professional before starting treatment, during treatment, and for any new or worsening eye problems. Tell your healthcare provider if you get any new or worsening eye problems including:
    • changes in vision, such as blurred vision, double vision, or vision loss
    • dry eye(s)
    • eye and eyelid inflammation, including redness, swelling, and itching
    • eye pain
    • new or increased floaters (small dark spots or squiggly lines that float across your vision)
    • light hurting eyes or seeing flashes of light
  • severe skin reactions. Skin reactions are common with Avmapki Fakzynja Co‑Pack and can be severe or life threatening. Tell your healthcare provider if you develop any new or worsening skin reactions including:
    • skin rash or acne
    • dry skin
    • itching
    • blisters on your skin
    • redness or swelling of your face, hands, or soles of your feet
    • blisters or sores in your mouth
    • peeling of your skin
    • skin infection
  • liver problems. Liver problems are common with Avmapki Fakzynja Co‑Pack and can be severe. Treatment with Avmapki Fakzynja Co‑Pack can increase the level of aspartate aminotransferase, alanine aminotransferase, and bilirubin in your blood. Your healthcare provider will do blood tests before starting each treatment cycle and during treatment to check your liver function. Tell your healthcare provider if you get any signs and symptoms of severe liver problems including:
    • yellowing of your skin or the white part of your eyes
    • itchy skin
    • feeling very tired
    • flu-like symptoms
    • nausea or vomiting
    • upper right side stomach pain
    • dark or tea colored urine
    • bleeding or bruising more easily than normal.
  • muscle problems (rhabdomyolysis). Avmapki Fakzynja Co‑Pack may cause muscle problems that can be severe. Treatment with Avmapki Fakzynja Co‑Pack can increase the level of an enzyme in your blood called creatine phosphokinase (CPK) and can be a sign of muscle damage. Your healthcare provider will perform blood tests to check your levels of CPK before starting each treatment cycle and during treatment. Tell your healthcare provider if you get any signs or symptoms of increased CPK including:
    • weakness or difficulty moving arms and legs
    • muscle or bone aches or pain that does not go away
    • dark, red colored urine or decreased urine output.

The most common side effects of Avmapki Fakzynja Co‑Pack include: nausea, tiredness, increased aspartate aminotransferase, diarrhea, swelling in the body (edema), decreased hemoglobin, increased alanine aminotransferase, vomiting, increased blood bilirubin, increased triglycerides, stomach-area pain, acid reflux, increased alkaline phosphatase, decreased platelets, constipation, shortness of breath, cough, urinary tract infection, decreased lymphocytes, decreased neutrophils, and proteinuria.

Avmapki Fakzynja Co‑Pack may cause fertility problems in females and males, which may affect your ability to have children. Talk to your healthcare provider if this is a concern for you.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all of the possible side effects of Avmapki Fakzynja Co‑Pack. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

What is Avmapki Fakzynja Co‑Pack?

Avmapki Fakzynja Co‑Pack is a prescription medicine used to treat adults who have:

  • low-grade serous ovarian cancer (LGSOC) that has come back (recurrent), and
  • LGSOC with an abnormal KRAS gene, and
  • previously been treated with medicine for their cancer.

It is not known if Avmapki Fakzynja Co‑Pack is safe and effective in children.

For additional safety information, please click here for full Prescribing Information and Patient Information and discuss with your doctor.